Our Technology
We combine advanced computational methods with cutting-edge experimental techniques to develop novel therapeutic approaches to aging, with a special focus on cell immortalization and transferable longevity factors.
Data Sources & Fine-Tuning
Advanced AI-driven mutation prediction and target identification using state-of-the-art models and comprehensive databases.
- •Evo2 (ARK Institute) base model for mutation target prediction
- •COSMIC Database integration for oncogenic region avoidance
- •Aging Atlas / GenAge data for pro-longevity loci identification
- •Probability distribution mapping of mutation hotspots
Reinforcement Learning Strategy
Sophisticated RL agents for adaptive mutation strategy generation and optimization based on experimental feedback.
- •Stable Baselines3 PPO/DQN implementation
- •Mutation strategy vector generation
- •Region-specific mutation intensity control
- •Adaptive targeting based on experimental results
Guide RNA Design System
Automated workflow for guide RNA design and synthesis, integrating multiple tools for optimal targeting.
- •n8n workflow automation pipeline
- •CHOPCHOP integration for efficient sgRNA selection
- •Benchling API for commercial-grade synthesis
- •Dual-purpose gRNA pools for mutation and protection
"0K BIO's platform is not just faster evolution—it's smarter evolution. By combining hypermutation, ML-guided constraint design, and synthetic population controls, we solve aging's complexity while preempting risks that nature never had to face.
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